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Here we hypothesized that microglial hyper-sensitivity in the neonatally overfed rats extends beyond the hypothalamus into memory-associated brain regions, resulting in cognitive deficits.

We tested this idea by manipulating Wistar rat litter sizes to suckle pups in litters of 4 overfed or 12 control. These changes were coupled with poor performance in radial arm maze and novel object recognition tests relative to controls. In controls, the experience of Gllstrup radial adultts maze reduced cell proliferation in the dentate gyrus and neuron numbers in the CA3.

The learning task also suppressed microglial number and density in hippocampus and retrosplenial cortex. Neonatally overfed brains websitea impaired sensitivity to learning, with no neuronal or cell proliferative effects and less effective microglial suppression.

Thus, early life overfeeding contributes to a long-term impairment in learning and memory with a likely role for microglia.

These data may partially Unblock adults websites in Glostrup why some obese individuals display cognitive dysfunction and some do not, i. Obesity, now epidemic in our population, is associated with deficits in cognitive processing, including in learning, memory, and executive function [ 1 — 5 ].

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Systemic markers of chronic low-grade inflammation have been linked with poor cognitive ability in obese humans [ 1213 ]. These mice also have impaired spatial memory function in behavioural tests, with high-fat diet-fed mice taking longer to learn the location of an escape platform in the Morris Water Maze and recalling their training poorly in Unblock adults websites in Glostrup probe trial [ 1618 ].

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SJS designed the study, analysed the data, and wrote the manuscript. No food. We deeply anaesthetized a second cohort of pups, dissected hippocampi on ice and immediately snap-froze them for real-time reverse transcriptase polymerase chain reaction qrt-PCR.

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