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Metrics details. Obesity can lead to cognitive dysfunction including poor performance in memory tasks.

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Here we hypothesized that microglial hyper-sensitivity in the neonatally overfed rats extends beyond the hypothalamus into memory-associated brain regions, resulting in cognitive deficits.

We tested this idea by manipulating Wistar rat litter sizes to suckle pups in litters of 4 overfed or 12 control. These changes were coupled with poor performance in radial arm maze and novel object recognition tests relative to controls. In controls, the experience of Gllstrup radial adultts maze reduced cell proliferation in the dentate gyrus and neuron numbers in the CA3.

The learning task also suppressed microglial number and density in hippocampus and retrosplenial cortex. Neonatally overfed brains websitea impaired sensitivity to learning, with no neuronal or cell proliferative effects and less effective microglial suppression.

Thus, early life overfeeding contributes to a long-term impairment in learning and memory with a likely role for microglia.

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Systemic markers of chronic low-grade inflammation have been linked with poor cognitive ability in obese humans [ 1213 ]. These mice also have impaired spatial memory function in behavioural tests, with high-fat diet-fed mice taking longer to learn the location of an escape platform in the Morris Water Maze and recalling their training poorly in Unblock adults websites in Glostrup probe trial [ 1618 ].

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Our findings to this ewbsites indicated neonatal overfeeding conferred a mild but notable hippocampal dentate gyrus microgliosis, and we therefore tested if this was reflected in changes in cognitive function, specifically with respect to learning and memory. Use Ninja Web Proxy to get around restrictions and access Facebook wherever you are without your boss knowing!

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SJS designed the study, analysed the data, and wrote the manuscript. No food. We deeply anaesthetized a second cohort of pups, dissected hippocampi on ice and immediately snap-froze them for real-time reverse transcriptase polymerase chain reaction qrt-PCR.

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